ABSTRACT
Aims:Coagulation profile shows the clotting ability of blood. Biochemical tests indicate health status of vital organs such as liver, heart and kidneys. Herbal products are being assessed for their role in affecting these parameters. We evaluated role of Foeniculumvulgareincorporated diet on coagulation profile and some important biochemical parameters.Study Design:Laboratory centred randomized controlled trial.Place and Duration of Study: Pharmacology Department of University of Karachi, Karachi between June 2018 and September 2018 Methodology: After selecting 30 healthy rabbits of either sex, we placed them in three groups; Control, 2% Foeniculumvulgareand 4% Foeniculumvulgaregroup. Control group was given standard diet whereas; 2% and 4% Foeniculumvulgaregroups were maintained on standard diet containing 2% and 4% Foeniculumvulgarecrushed seeds. Coagulation profile and some biochemical parameters were done after interval of a month, for two months.Results:Platelet count and fibrinogen increased while activated partial thromboplastin time (APTT) levels decreased in both the study groups animals as compared to control, while blood urea nitrogen (BUN), creatinine phosphokinase (CPK) and lactate dehydrogenase (LDH) elevation was noted both Foeniculumvulgaregroups but within normal range.Conclusion:Foeniculumvulgaremay have some role in affecting coagulation and biochemical profile These parameters, however, need clinical trial to validate reliability